Pharmacogenetics: A Precision Medicine Approach to Combatting the Opioid Epidemic.

ABSTRACT: Ineffective pain control is the most commonly cited reason for misuse of prescription opioids and is influenced by genetics. In particular, the gene encoding the CYP2D6 enzyme, which metabolizes some of the most commonly prescribed opioids (e.g., tramadol, hydrocodone) to their more potent forms, is highly polymorphic and can lead to reduced concentrations of the active metabolites and decreased opioid effectiveness. Consideration of the CYP2D6 genotype may allow for predicting opioid response and identifying patients who are likely to respond well to lower potency opioids as well as those who may derive greater pain relief from non-opioid analgesics versus certain opioids. There is emerging evidence that a CYP2D6-guided approach to pain management improves pain control and r

SUBMITTER: Smith DM 

PROVIDER: S-EPMC9248444 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature