Transposable element accumulation drives size differences among polymorphic Y Chromosomes in Drosophila.

ABSTRACT: Y Chromosomes of many species are gene poor and show low levels of nucleotide variation, yet they often display high amounts of structural diversity. Dobzhansky cataloged several morphologically distinct Y Chromosomes in Drosophila pseudoobscura that differ in size and shape, but the molecular causes of their large size differences are unclear. Here we use cytogenetics and long-read sequencing to study the sequence content of polymorphic Y Chromosomes in D. pseudoobscura We show that Y Chromosomes differ almost twofold in size, ranging from 30 to 60 Mb. Most of this size difference is caused by a handful of active transposable elements (TEs) that have recently expanded on the largest Y Chromosome, with different elements being responsible for Y expansion on differently sized

SUBMITTER: Nguyen AH 

PROVIDER: S-EPMC9248874 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature