Ontology highlight
ABSTRACT:
SUBMITTER: Xu W
PROVIDER: S-EPMC9248879 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Xu Wenli W Liu Chang C Deng Bing B Lin Penghui P Sun Zhenghua Z Liu Anrui A Xuan Jiajia J Li Yuying Y Zhou Keren K Zhang Xiaoqin X Huang Qiaojuan Q Zhou Hui H He Qingyu Q Li Bin B Qu Lianghu L Yang Jianhua J
Genome research 20220524 6
Polypeptides encoded by long noncoding RNAs (lncRNAs) are a novel class of functional molecules. However, whether these hidden polypeptides participate in the TP53 pathway and play a significant biological role is still unclear. Here, we discover that TP53-regulated lncRNAs can encode peptides, two of which are functional in various human cell lines. Using ribosome profiling and RNA-seq approaches in HepG2 cells, we systematically identified more than 300 novel TP53-regulated lncRNAs and further ...[more]