A structured model and likelihood approach to estimate yeast prion propagon replication rates and their asymmetric transmission.

ABSTRACT: Prion proteins cause a variety of fatal neurodegenerative diseases in mammals but are generally harmless to Baker's yeast (Saccharomyces cerevisiae). This makes yeast an ideal model organism for investigating the protein dynamics associated with these diseases. The rate of disease onset is related to both the replication and transmission kinetics of propagons, the transmissible agents of prion diseases. Determining the kinetic parameters of propagon replication in yeast is complicated because the number of propagons in an individual cell depends on the intracellular replication dynamics and the asymmetric division of yeast cells within a growing yeast cell colony. We present a structured population model describing the distribution and replication of prion propagons in an actively dividing

SUBMITTER: Santiago F 

PROVIDER: S-EPMC9249220 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature