Association between dopamine receptor D2 Taq IA gene polymorphism and persistent postural-perceptual dizziness.

ABSTRACT:

Background

Persistent postural-perceptual dizziness (PPPD) is a chronic dizziness, its pathogenesis is unknown by now.

Objective

To study the relationship between the DRD2 gene TaqIA polymorphisms and PPPD, and further to explore the molecular mechanism underlying this disease.

Methods

43 patients diagnosed with PPPD and 45 randomly selected cases (matched by age and sex) were included in the study and control group, respectively. DRD2 gene TaqIA polymorphisms were detected in all participants by polymerase chain reaction (PCR)combined with the restriction fragment length polymorphism (RFLP) method.

Results

In the study group, frequencies of the A1 and A2 TaqIA alleles (65.1% and 34.9%, respectively) were significantly different to those in the control group (4

SUBMITTER: Cui L 

PROVIDER: S-EPMC9249288 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature