Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells.

ABSTRACT: The epithelial-mesenchymal transition (EMT) is a crucial morphological event that occurs during epithelial tumor progression. Snail and ZEB1/2 (ZEB1 and ZEB2), known as EMT transcription factors, are key regulators of this transition. ZEB1/2 are positively correlated with EMT phenotypes and the aggressiveness of cancers. On the contrary, Snail is also correlated with the aggressiveness of cancers, but is not correlated with the expression of EMT marker proteins. Snail is induced by transforming growth factor-β (TGF-β), a well-known inducer of EMT, in various cancer cells. Interestingly, Snail induction by TGF-β is markedly enhanced by active Ras signals. Thus, cancer cells harboring an active Ras mutation exhibit a drastic induction of Snail by TGF-β alone. Here, we found that members of t

SUBMITTER: Ichikawa MK 

PROVIDER: S-EPMC9249322 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature