Ontology highlight
ABSTRACT:
SUBMITTER: Yoo HS
PROVIDER: S-EPMC9249609 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Yoo Hong Sik HS Rodriguez Adrienne A You Dongjoo D Lee Rebecca A RA Cockrum Michael A MA Grimes Jack A JA Wang Jen-Chywan JC Kang Sona S Napoli Joseph L JL
iScience 20220609 7
Retinoic acid (RA) counters insulin's metabolic actions. Insulin reduces liver RA biosynthesis by exporting FoxO1 from nuclei. RA induces its catabolism, catalyzed by CYP26A1. A CYP26A1 contribution to RA homeostasis with changes in energy status had not been investigated. We found that glucagon, cortisol, and dexamethasone decrease RA-induced <i>CYP26A1</i> transcription, thereby reducing RA oxidation during fasting. Interaction between the glucocorticoid receptor and the RAR/RXR coactivation c ...[more]