Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film.

ABSTRACT: Implantable biomaterials are widely used in the curative resection and palliative treatment of various types of cancers. However, cancer residue around the implants usually leads to treatment failure with cancer reoccurrence. Postoperation chemotherapy and radiation therapy are widely applied to clear the residual cancer cells but induce serious side effects. It is urgent to develop advanced therapy to minimize systemic toxicity while maintaining efficient cancer-killing ability. Herein, we report a degenerate layered double hydroxide (LDH) film modified implant, which realizes microenvironment-responsive electrotherapy. The film can gradually transform into a nondegenerate state and release holes. When in contact with tumor cells or bacteria, the film quickly transforms into a nondegenera

SUBMITTER: Wang D 

PROVIDER: S-EPMC9249615 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature