Ontology highlight
ABSTRACT:
SUBMITTER: Makowski EK
PROVIDER: S-EPMC9249733 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Makowski Emily K EK Kinnunen Patrick C PC Huang Jie J Wu Lina L Smith Matthew D MD Wang Tiexin T Desai Alec A AA Streu Craig N CN Zhang Yulei Y Zupancic Jennifer M JM Schardt John S JS Linderman Jennifer J JJ Tessier Peter M PM
Nature communications 20220701 1
Therapeutic antibody development requires selection and engineering of molecules with high affinity and other drug-like biophysical properties. Co-optimization of multiple antibody properties remains a difficult and time-consuming process that impedes drug development. Here we evaluate the use of machine learning to simplify antibody co-optimization for a clinical-stage antibody (emibetuzumab) that displays high levels of both on-target (antigen) and off-target (non-specific) binding. We mutate ...[more]