Design, fabrication and testing of 3D printed smartphone-based device for collection of intrinsic fluorescence from human cervix.

ABSTRACT: Fluorescence spectroscopy has the potential to identify discriminatory signatures, crucial for early diagnosis of cervical cancer. We demonstrate here the design, fabrication and testing of a 3D printed smartphone based spectroscopic device. Polarized fluorescence and elastic scattering spectra are captured through the device using a 405 nm laser and a white LED source respectively. The device has been calibrated by comparison of spectra of standard fluorophores (Flavin adenine dinucleotide, fluorescein, rhodamine, and porphyrin) with the corresponding spectra collected from a commercial spectrometer. A few cervical tissue spectra have also been captured for proof of its applicability as a portable, standalone device for the collection of intrinsic fluorescence spectra from human cervix.

SUBMITTER: Shukla S 

PROVIDER: S-EPMC9249735 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature