Ontology highlight
ABSTRACT:
SUBMITTER: Bazioti V
PROVIDER: S-EPMC9249754 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Bazioti Venetia V La Rose Anouk M AM Maassen Sjors S Bianchi Frans F de Boer Rinse R Halmos Benedek B Dabral Deepti D Guilbaud Emma E Flohr-Svendsen Arthur A Groenen Anouk G AG Marmolejo-Garza Alejandro A Koster Mirjam H MH Kloosterhuis Niels J NJ Havinga Rick R Pranger Alle T AT Langelaar-Makkinje Miriam M de Bruin Alain A van de Sluis Bart B Kohan Alison B AB Yvan-Charvet Laurent L van den Bogaart Geert G Westerterp Marit M
Nature communications 20220701 1
Atherosclerosis is a chronic inflammatory disease driven by hypercholesterolemia. During aging, T cells accumulate cholesterol, potentially affecting inflammation. However, the effect of cholesterol efflux pathways mediated by ATP-binding cassette A1 and G1 (ABCA1/ABCG1) on T cell-dependent age-related inflammation and atherosclerosis remains poorly understood. In this study, we generate mice with T cell-specific Abca1/Abcg1-deficiency on the low-density-lipoprotein-receptor deficient (Ldlr<sup> ...[more]