Utilization of dielectric properties for assessment of liver ischemia-reperfusion injury in vivo and during machine perfusion.

ABSTRACT: There is a shortage of donor livers and patients consequently die on waiting lists worldwide. Livers are discarded if they are clinically judged to have a high risk of non-function following transplantation. With the aim of extending the pool of available donor livers, we assessed the condition of porcine livers by monitoring the microwave dielectric properties. A total of 21 livers were divided into three groups: control with no injury (CON), biliary injury by hepatic artery occlusion (AHEP), and overall hepatic injury by static cold storage (SCS). All were monitored for four hours in vivo, followed by ex vivo plurithermic machine perfusion (PMP). Permittivity data was modeled with a two-pole Cole-Cole equation, and dielectric properties from one-hour intervals were analyzed during in viv

SUBMITTER: Hou J 

PROVIDER: S-EPMC9249774 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature