Analysis of nestin protein in the aqueous humor as biomarker of open angle glaucoma.

ABSTRACT: Primary open angle glaucoma (POAG) is a progressive optic nerve degeneration, leading to irreversible visual damage. Alterations of the aqueous humor (AH), the biological fluid filling both the anterior and the posterior chambers of the eye, play a pathogenic role in POAG. AH protein composition is altered during glaucoma progression. Nestin protein was found to be differentially expressed in the AH of glaucomatous patients compared to unaffected matched controls.

Methods

Nestin was analyzed by an open quartz crystal microbalance (QCM) in the AH of 21 glaucomatous patients compared to nine unaffected controls. The surface of the electrode used in the QCM was coated with an analyte-specific recognition layer.

Results

Positive nestin values were recorded in the AH collected fro

SUBMITTER: Pulliero A 

PROVIDER: S-EPMC9249827 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature