Monovalent ions and stress-induced senescence in human mesenchymal endometrial stem/stromal cells.

ABSTRACT: Monovalent ions are involved in growth, proliferation, differentiation of cells as well as in their death. This work concerns the ion homeostasis during senescence induction in human mesenchymal endometrium stem/stromal cells (hMESCs): hMESCs subjected to oxidative stress (sublethal pulse of H₂O₂) enter the premature senescence accompanied by persistent DNA damage, irreversible cell cycle arrest, increased expression of the cell cycle inhibitors (p53, p21) cell hypertrophy, enhanced β-galactosidase activity. Using flame photometry to estimate K⁺, Na⁺ content and Rb⁺ (K⁺) fluxes we found that during the senescence development in stress-induced hMESCs, Na⁺/K⁺pump-mediated K⁺ fluxes are enhanced

SUBMITTER: Shatrova A 

PROVIDER: S-EPMC9249837 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature