Differential epithelial and stromal LGR5 expression in ovarian carcinogenesis.

ABSTRACT: Lgr5 has been identified as a marker of the stem/progenitor cells in the murine ovary and oviduct by lineage tracing. However, little is known regarding LGR5 expression or its functional significance in human ovary tissues. Here, using RNA in situ hybridization and/or immunohistochemistry, we thoroughly investigated LGR5 expression in normal human ovaries, fallopian tubes and various ovarian tumors. We discovered that LGR5 expression is negligible in the human ovary surface epithelium, whereas ovarian stromal cells normally express low levels of LGR5. Remarkably, fallopian tube epithelium, inclusion cysts and serous cystadenomas with a Müllerian phenotype expressed high levels of LGR5, and LGR5 expression was restricted to PAX8⁺/FOXJ1^- secretory cells of the tubal epi

SUBMITTER: Kim H 

PROVIDER: S-EPMC9249864 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature