Intestine-enriched apolipoprotein b orthologs are required for stem cell progeny differentiation and regeneration in planarians.

ABSTRACT: Lipid metabolism plays an instructive role in regulating stem cell state and differentiation. However, the roles of lipid mobilization and utilization in stem cell-driven regeneration are unclear. Planarian flatworms readily restore missing tissue due to injury-induced activation of pluripotent somatic stem cells called neoblasts. Here, we identify two intestine-enriched orthologs of apolipoprotein b, apob-1 and apob-2, which mediate transport of neutral lipid stores from the intestine to target tissues including neoblasts, and are required for tissue homeostasis and regeneration. Inhibition of apob function by RNAi causes head regression and lysis in uninjured animals, and delays body axis re-establishment and regeneration of multiple organs in amputated fragments. Furthermore, apob RNAi

SUBMITTER: Wong LL 

PROVIDER: S-EPMC9249923 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature