Salivary biomarkers in breast cancer diagnosis: A systematic review and diagnostic meta-analysis.

ABSTRACT:

Background

Salivary diagnostics and their utility as a nonaggressive approach for breast cancer diagnosis have been extensively studied in recent years. This meta-analysis assesses the diagnostic value of salivary biomarkers in differentiating between patients with breast cancer and controls.

Methods

We conducted a meta-analysis and systematic review of studies related to salivary diagnostics published in PubMed, EMBASE, Scopus, Ovid, Science Direct, Web of Science (WOS), and Google Scholar. The articles were chosen utilizing inclusion and exclusion criteria, as well as assessing their quality. Specificity and sensitivity, along with negative and positive likelihood ratios (NLR and PLR) and diagnostic odds ratio (DOR), were calculated based on random- or fixed-effects model.

SUBMITTER: Koopaie M 

PROVIDER: S-EPMC9249990 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature