A multi-organ chip with matured tissue niches linked by vascular flow.

ABSTRACT: Engineered tissues can be used to model human pathophysiology and test the efficacy and safety of drugs. Yet, to model whole-body physiology and systemic diseases, engineered tissues with preserved phenotypes need to physiologically communicate. Here we report the development and applicability of a tissue-chip system in which matured human heart, liver, bone and skin tissue niches are linked by recirculating vascular flow to allow for the recapitulation of interdependent organ functions. Each tissue is cultured in its own optimized environment and is separated from the common vascular flow by a selectively permeable endothelial barrier. The interlinked tissues maintained their molecular, structural and functional phenotypes over 4 weeks of culture, recapitulated the pharmacokinetic and pha

SUBMITTER: Ronaldson-Bouchard K 

PROVIDER: S-EPMC9250010 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature