An accumulation of muscle macrophages is accompanied by altered insulin sensitivity after reduced activity and recovery.

ABSTRACT:

Background

Mechanisms underlying physical inactivity-induced insulin resistance are not well understood. In addition to a role in muscle repair, immune cell populations such as macrophages may regulate insulin sensitivity.

Aim

The aim of this study was to examine if the dynamic changes in insulin sensitivity during and after recovery from reduced physical activity corresponded to changes in skeletal muscle macrophages.

Methods

In this prospective clinical study, we collected muscle biopsies from healthy older adults (70 ± 2 years, n = 12) before and during a hyperinsulinaemic-euglycaemic clamp and this occurred before (PRE) and after 2-week reduced physical activity (RA), and following 2-week of recovery (REC). Insulin sensitivity (hyperinsulinaemic-euglycaemic clamp)

SUBMITTER: Reidy PT 

PROVIDER: S-EPMC9250031 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature