Resilience or susceptibility to traumatic stress: Potential influence of the microbiome.

ABSTRACT: Exposure to traumatic stress is a major risk factor for development of neuropsychiatric disorders in a sub-population of individuals, while others remain resilient. The mechanisms and contributing factors differentiating between these phenotypes are still unclear. We hypothesize that inter-individual differences in the microbial composition and function contribute to host resilience or susceptibility to stress-induced psychopathologies. The current study aimed to characterize gut microbial community before and after exposure to traumatic stress in an animal model of PTSD. Sprague-Dawley male rats were randomly divided into unstressed controls and experimental group subjected to Single Prolonged Stress (SPS). After 14 days, behavioral analyses were performed using Open Field, Social Interac

SUBMITTER: Tanelian A 

PROVIDER: S-EPMC9250071 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature