A New Paradigm of Multiheme Cytochrome Evolution by Grafting and Pruning Protein Modules.

ABSTRACT: Multiheme cytochromes play key roles in diverse biogeochemical cycles, but understanding the origin and evolution of these proteins is a challenge due to their ancient origin and complex structure. Up until now, the evolution of multiheme cytochromes composed by multiple redox modules in a single polypeptide chain was proposed to occur by gene fusion events. In this context, the pentaheme nitrite reductase NrfA and the tetraheme cytochrome c554 were previously proposed to be at the origin of the extant octa- and nonaheme cytochrome c involved in metabolic pathways that contribute to the nitrogen, sulfur, and iron biogeochemical cycles by a gene fusion event. Here, we combine structural and character-based phylogenetic analysis with an unbiased root placement method to refine the evolutiona

SUBMITTER: Soares R 

PROVIDER: S-EPMC9250108 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature