Additive effects of blood donor smoking and gamma irradiation on outcome measures of red blood cell transfusion.

ABSTRACT:

Background

Recent publications have reported conflicting results regarding the role of blood donor tobacco use on hemoglobin (Hb) levels in patients after red blood cell (RBC) transfusion. We examined associations and interactions between donor, component, and recipient factors to better understand the impact of donor smoking on transfusion outcomes.

Study design and methods

We linked blood donor and component manufacturing data, including self-reported cigarette smoking, with a cohort of patients transfused RBCs between 2013 and 2016. Using multivariable regression, we examined Hb increments and subsequent transfusion requirements after single-unit RBC transfusion episodes, adjusting for donor, component, and recipient factors.

Results

We linked data on 4038 transfus

SUBMITTER: DeSimone RA 

PROVIDER: S-EPMC9250110 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature