Poor reproducibility of percentage of normally shaped sperm using the World Health Organization Fifth Edition strict grading criteria.

ABSTRACT:

Objective

To determine the reproducibility of the World Health Organization Fifth Edition (WHO5) strict grading methodology by comparing the percentage of morphologically normal sperm (PNS) recorded by the core laboratory with results obtained at the fertility centers participating in a multisite clinical trial.

Design

Secondary cohort analysis of data from the Males, Antioxidants, and Infertility trial.

Setting

Fertility centers.

Patients

Semen values of 171 men participating in a multicenter, double-blind, randomized, placebo-controlled trial evaluating the effect of antioxidants on male fertility.

Interventions

Not applicable.

Main outcome measures

Strict morphology expressed as PNS as determined at each fertility center and the core central la

SUBMITTER: Baker KC 

PROVIDER: S-EPMC9250115 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature