Dietary adenosine 5'-monophosphate supplementation increases food intake and remodels energy expenditure in mice.

ABSTRACT:

Background

Dietary nucleotides [inclusion adenosine 5'-monophosphate (AMP)] supplementation was shown to promote the feed intake of sows and increase the AMP content in their milk in our previous work, but whether AMP shapes the energy expenditure and lipid metabolism in mammals remains unknown. Here, we aimed to explore the effects and the related mechanism of dietary AMP supplementation on food intake, body composition, energy expenditure, and lipid metabolism in male mice.

Methods

4-week-old C57BL/6 mice (After a 1-wk adaptation) were fed with basal diet and basal diet supplemented with 0.1% AMP, respectively. Animal food intake and body weight were monitored and after 4 weeks all animals were sacrificed to measure the body composition, energy expenditure and lipid metabo

SUBMITTER: Wu Z 

PROVIDER: S-EPMC9250134 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature