Effect of norepinephrine infusion on hepatic blood flow and its interaction with somatostatin: an observational cohort study.

ABSTRACT:

Background

Norepinephrine (NE) is a α₁-adrenergic mediated vasopressor and a key player in the treatment of perioperative hypotension. Apart from modulating systemic hemodynamics, NE may also affect regional blood flow, such as the hepatic circulation, which contains a wide variety of adrenergic receptors. It may alter regional vascular tonus and hepatic blood flow (HBF) by reducing portal vein flow (PVF) or hepatic arterial flow (HAF). The aim of this study was to assess the effects of NE on HBF.

Methods

Patients scheduled for pancreaticoduodenectomy were included. All patients received standardized anesthetic care using propofol and remifentanil and were hemodynamically stabilized using a goal-directed hemodynamic strategy guided by Pulsioflex™. On surgical indi

SUBMITTER: van Limmen J 

PROVIDER: S-EPMC9250229 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature