Galectin-4 levels in hospitalized versus non-hospitalized subjects with obesity: the Malmo Preventive Project.

ABSTRACT:

Background

Obesity is strongly associated with the development of cardiovascular disease (CVD). However, the heterogenous nature of obesity in CVD-risk is still poorly understood. We aimed to explore novel CVD biomarkers and their possible association with presumed unhealthy obesity, defined as hospitalized subjects with obesity (HO).

Methods

Ninety-two proteins associated with CVD were analyzed in 517 (mean age 67 ± 6 years; 33.7% women) individuals with obesity (BMI ≥30 kg/m²) from the Malmö Preventive Project cohort, using a proximity extension array technique from the Olink CVD III panel. Individuals with at least one recorded hospitalization for somatic disease prior to study baseline were defined as HO phenotypes. Associations between proteins and HO (n = 40

SUBMITTER: Korduner J 

PROVIDER: S-EPMC9250274 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature