Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior.

ABSTRACT: Childhood maladaptive aggression is associated with disrupted functional connectivity within amygdala-prefrontal circuitry. In this study, neural correlates of childhood aggression were probed using the intrinsic connectivity distribution, a voxel-wise metric of global resting-state brain connectivity. This sample included 38 children with aggressive behavior (26 boys, 12 girls) ages 8-16 years and 21 healthy controls (14 boys, 6 girls) matched for age and IQ. Functional MRI data were acquired during resting state, and differential patterns of intrinsic functional connectivity were tested in a priori regions of interest implicated in the pathophysiology of aggressive behavior. Next, correlational analyses tested for associations between functional connectivity and severity of aggression me

SUBMITTER: Sukhodolsky DG 

PROVIDER: S-EPMC9250305 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature