A mechanistic motor-clutch model that explains cell shape dynamics to cyclic stretch.

ABSTRACT: Many cells in the body experience cyclic mechanical loading, which can impact cellular processes and morphology. In vitro studies often report that cells reorient in response to cyclic stretch of their substrate. To explore cellular mechanisms involved in this reorientation, a computational model was developed by adapting previous computational models of the actin-myosin-integrin motor-clutch system developed by others. The computational model predicts that under most conditions, actin bundles align perpendicular to the direction of applied cyclic stretch, but under specific conditions, such as low substrate stiffness, actin bundles align parallel to the direction of stretch. The model also predicts that stretch frequency impacts the rate of reorientation and that proper myosin function is

SUBMITTER: Scandling BW 

PROVIDER: S-EPMC9250388 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature