TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.
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ABSTRACT:
SUBMITTER: Meena AS
PROVIDER: S-EPMC9250449 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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TRPV6 channel mediates alcohol-induced gut barrier dysfunction and systemic response.
Meena Avtar S AS Shukla Pradeep K PK Bell Briar B Giorgianni Francesco F Caires Rebeca R Fernández-Peña Carlos C Beranova Sarka S Aihara Eitaro E Montrose Marshall H MH Chaib Mehdi M Makowski Liza L Neeli Indira I Radic Marko Z MZ Vásquez Valeria V Jaggar Jonathan H JH Cordero-Morales Julio F JF Rao RadhaKrishna R
Cell reports 20220601 11
Intestinal epithelial tight junction disruption is a primary contributing factor in alcohol-associated endotoxemia, systemic inflammation, and multiple organ damage. Ethanol and acetaldehyde disrupt tight junctions by elevating intracellular Ca<sup>2+</sup>. Here we identify TRPV6, a Ca<sup>2+</sup>-permeable channel, as responsible for alcohol-induced elevation of intracellular Ca<sup>2+</sup>, intestinal barrier dysfunction, and systemic inflammation. Ethanol and acetaldehyde elicit TRPV6 ioni ...[more]
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