The different prognostic significance of polysialic acid and CD56 expression in tumor cells and lymphocytes identified in breast cancer.

ABSTRACT: Protein glycosylation, the attachment of carbohydrates onto proteins, is a fundamental process that alters the biological activity of proteins. Changes to glycosylation states are associated with many forms of cancer including breast cancer. Through immunohistological analysis of breast cancer patient tumors, we have discovered the expression of an atypical glycan-polysialic acid (polySia)-in breast cancer. Notably, we have identified polySia expression in not only tumor cells but also on tumor-infiltrating lymphocytes (TILs) and our study reveals ST8Sia4 as the predominant polysialyltransferase expressed. Evaluation of ST8Sia4 expression in tumor cells identified an association between high expression levels and poor patient outcomes whereas ST8Sia4 expression in infiltrating stromal cell

SUBMITTER: Soukhtehzari S 

PROVIDER: S-EPMC9250520 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature