Identification of the high-yield monacolin K strain from Monascus spp. and its submerged fermentation using different medicinal plants.

ABSTRACT:

Background

Medical plants confer various benefits to human health and their bioconversion through microbial fermentation can increase efficacy, reduce toxicity, conserve resources and produce new chemical components. In this study, the cholesterol-lowering monacolin K genes and content produced by Monascus species were identified. The high-yield monacolin K strain further fermented with various medicinal plants. The antioxidant and anti-inflammatory activities, red pigment and monacolin K content, total phenolic content, and metabolites in the fermented products were analyzed.

Results

Monacolin K was detected in Monascus pilosus (BCRC 38072), and Monascus ruber (BCRC 31533, 31523, 31534, 31535, and 33323). It responded to the highly homologous mokA and mokE genes encoding po

SUBMITTER: Chen YP 

PROVIDER: S-EPMC9250582 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature