Methylation Subtypes of Primary Prostate Cancer Predict Poor Prognosis.

ABSTRACT:

Background

Patients with prostate cancer experience heterogeneous outcomes after radical prostatectomy. Genomic studies including The Cancer Genome Atlas (TCGA) have reported molecular signatures of prostate cancer, but few studies have assessed the prognostic effects of DNA methylation profiles.

Methods

We conducted the largest methylome subtyping analysis for primary prostate tumors to date, using methylome data from three patient populations: TCGA, a prostate cancer cohort study conducted at the Fred Hutchinson Cancer Research Center (FH; Seattle, WA), and the Canadian International Cancer Genome Consortium (ICGC) cohort. Four subtypes were detected in the TCGA dataset, then independently assigned to FH and ICGC cohort data. The identified methylation subtypes were assess

SUBMITTER: Wang X 

PROVIDER: S-EPMC9250603 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature