On the role of skeletal muscle acidosis and inorganic phosphates as determinants of central and peripheral fatigue: A ³¹ P-MRS study.

ABSTRACT: Intramuscular hydrogen ion (H⁺ ) and inorganic phosphate (Pi) concentrations were dissociated during exercise to challenge their relationships with peripheral and central fatigue in vivo. Ten recreationally active, healthy men (27 ± 5 years; 180 ± 4 cm; 76 ± 10 kg) performed two consecutive intermittent isometric single-leg knee-extensor trials (60 maximal voluntary contractions; 3 s contraction, 2 s relaxation) interspersed with 5 min of rest. Phosphorus magnetic resonance spectroscopy (³¹ P-MRS) was used to continuously quantify intramuscular [H⁺ ] and [Pi] during both trials. Using electrical femoral nerve stimulation, quadriceps twitch force (Q_tw ) and voluntary activation (VA) were quantified at rest and throughout both trials. Decreases in

SUBMITTER: Hureau TJ 

PROVIDER: S-EPMC9250628 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature