Association between lipid profiles and viral respiratory infections in human sputum samples.

ABSTRACT:

Background

Respiratory infections such as influenza account for significant global mortality each year. Generating lipid profiles is a novel and emerging research approach that may provide new insights regarding the development and progression of priority respiratory infections. We hypothesized that select clusters of lipids in human sputum would be associated with specific viral infections (Influenza (H1N1, H3N2) or Rhinovirus).

Methods

Lipid identification and semi-quantitation was determined with liquid chromatography and high-resolution mass spectrometry in induced sputum from individuals with confirmed respiratory infections (influenza (H1N1, H3N2) or rhinovirus). Clusters of lipid species and associations between lipid profiles and the type of respiratory viral agent w

SUBMITTER: Humes ST 

PROVIDER: S-EPMC9250719 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature