Reduced frequencies of Foxp3⁺GARP⁺ regulatory T cells in COPD patients are associated with multi-organ loss of tissue phenotype.

ABSTRACT:

Background

Expression of glycoprotein A dominant repeat (GARP) has been reported to occur only in activated human naturally occurring regulatory T cells (Tregs) and their clones, and not in activated effector T cells, indicating that GARP is a marker for bona fide Tregs. A different phenotype of chronic obstructive pulmonary disease (COPD) may have a different immunologic mechanism.

Objective

To investigate whether the distribution of Tregs defined by GARP is related to the multi-organ loss of tissue phenotype in COPD.

Methods

GARP expression on T cells from peripheral blood and bronchoalveolar lavage (BAL) collected from patients with COPD was examined by flow cytometry. The correlation of GARP expression to clinical outcomes and clinical phenotype, including the bod

SUBMITTER: Hou J 

PROVIDER: S-EPMC9250745 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature