COVID-19 vaccination efficacy in numbers including SARS-CoV-2 variants and age comparison: a meta-analysis of randomized clinical trials.

ABSTRACT:

Background

New vaccines are being developed to fight the ongoing COVID-19 pandemic. In our study we compared the efficacy of COVID-19 vaccines to prevent COVID-19-related infections and mortality.

Methods

17 randomized clinical trials of COVID-19 vaccines were included after search in databases. We compared COVID-19 vaccines based on symptomatic and severe infections, number of deaths and hospitalizations related to COVID-19. Also, we analyzed the efficacy of COVID-19 against different variants of SARS-CoV-2 as well as according to different age groups. Random effects model using Mantel-Haenzeal method was used to pool relative risk (RR).

Results

Our meta-analysis shows that full vaccination could decrease not only the risk of symptomatic or severe COVID-19, the risk

SUBMITTER: Sobczak M 

PROVIDER: S-EPMC9250750 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature