Liver Environment-Imposed Constraints Diversify Movement Strategies of Liver-Localized CD8 T Cells.

ABSTRACT: Pathogen-specific CD8 T cells face the problem of finding rare cells that present their cognate Ag either in the lymph node or in infected tissue. Although quantitative details of T cell movement strategies in some tissues such as lymph nodes or skin have been relatively well characterized, we still lack quantitative understanding of T cell movement in many other important tissues, such as the spleen, lung, liver, and gut. We developed a protocol to generate stable numbers of liver-located CD8 T cells, used intravital microscopy to record movement patterns of CD8 T cells in livers of live mice, and analyzed these and previously published data using well-established statistical and computational methods. We show that, in most of our experiments, Plasmodium-specific liver-localized CD

SUBMITTER: Rajakaruna H 

PROVIDER: S-EPMC9250760 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature