Mutational Analysis of Triple-Negative Breast Cancer Using Targeted Kinome Sequencing.

ABSTRACT:

Purpose

Triple-negative breast cancer (TNBC) does not have defined therapeutic targets and is currently treated with chemotherapy only. Kinase dysregulation triggers cancer cell proliferation and metastasis and is a crucial therapeutic target for cancer. In this study, targeted kinome sequencing of TNBC tumors was performed to assess the association between kinome gene alterations and disease outcomes in TNBC.

Methods

A kinome gene panel consisting of 612 genes was used for the targeted sequencing of 166 TNBC samples and matched normal tissues. Analyses of the significantly mutated genes were performed. Genomic differences between Asian and non-Asian patients with TNBC were evaluated using two Asian TNBC datasets (from Seoul National University Hospital [SNUH] and Fudan Univ

SUBMITTER: Yoo TK 

PROVIDER: S-EPMC9250872 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature