Fluid accumulation and major adverse kidney events in sepsis: a multicenter observational study.

ABSTRACT:

Background

Whether early fluid accumulation is a risk factor for adverse renal outcomes in septic intensive care unit (ICU) patients remains uncertain. We assessed the association between cumulative fluid balance and major adverse kidney events within 30 days (MAKE30), a composite of death, dialysis, or sustained renal dysfunction, in such patients.

Methods

We performed a multicenter, retrospective observational study in 1834 septic patients admitted to five ICUs in three hospitals in Stockholm, Sweden. We used logistic regression analysis to assess the association between cumulative fluid balance during the first two days in ICU and subsequent risk of MAKE30, adjusted for demographic factors, comorbidities, baseline creatinine, illness severity variables, haemodynamic chara

SUBMITTER: Mele A 

PROVIDER: S-EPMC9250912 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature