Ozone as an adjuvant therapy for COVID-19: A systematic review and meta-analysis.

ABSTRACT:

Objective

Ozone adjuvant in COVID-19 management showed conflicting results in prior studies. Here, we aimed to comprehensively evaluate benefits and side effects of ozone as adjuvant therapy in COVID-19 patients.

Methods

Systematic searches were conducted in MEDLINE, ScienceDirect, Cochrane Library, Springer, medRxiv, and ProQuest for articles investigating ozone as adjuvant therapy in COVID-19. Clinical and laboratory outcomes, mortality, length of hospital stay, intensive care unit (ICU) admission, and adverse events were assessed.

Results

Thirteen studies were included in this review. Case-control studies, but not randomized controlled trials (RCTs), showed a decrease in mortality following ozone therapy (OR = 0.24 (95% CI [0.07-0.76]), p = 0.02, I² = 0%

SUBMITTER: Setyo Budi D 

PROVIDER: S-EPMC9250927 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature