Improving the external validity of Antenatal Late Preterm Steroids trial findings.

ABSTRACT:

Background

The external validity of randomised trials can be compromised when trial participants differ from real-world populations. In the Antenatal Late Preterm Steroids (ALPS) trial of antenatal corticosteroids at late preterm ages, participants had systematically younger gestational ages than those outside the trial setting. As risk of respiratory morbidity (the primary trial outcome) is higher at younger gestations, absolute benefits of corticosteroids calculated in the trial population may overestimate real-world treatment benefits.

Objectives

To estimate the real-world absolute risk reduction and number-needed-to-treat (NNT) for antenatal corticosteroids at late preterm ages, accounting for gestational age differences between the ALPS and real-world populations.

Me

SUBMITTER: Hutcheon JA 

PROVIDER: S-EPMC9250943 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature