Urinary Fatty Acid Binding Protein 3 Has Prognostic Value in Peripheral Artery Disease.

ABSTRACT:

Background

Despite its significant association with limb loss and death, peripheral artery disease (PAD) remains underdiagnosed and undertreated. The current accepted gold-standard for PAD screening, the ankle brachial index (ABI), is limited by operator dependence, erroneous interpretation, and unreliability in patients with diabetes. Fatty acid binding protein 3 (FABP3) is an intracellular protein that becomes released into circulation and excreted into urine following skeletal muscle injury. We examined the prognostic ability of urinary FABP3 (uFABP3) in predicting adverse PAD-related events.

Methods

In this prospective case-control study, urine samples were collected from patients with PAD (n = 142) and without PAD (n = 72). The cohort was followed for 2 ye

SUBMITTER: Li B 

PROVIDER: S-EPMC9250966 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature