Biochemical and Endocrine Parameters for the Discrimination and Calibration of Bipolar Disorder or Major Depressive Disorder.

ABSTRACT:

Objectives

Conventional biochemical indexes may have predictive values in clinical identification between bipolar disorder (BD) and major depressive disorder (MDD).

Methods

This study included 2,470 (BD/MDD = 1,333/1,137) hospitalized patients in Shanghai as training sets and 2,143 (BD/MDD = 955/1,188) in Hangzhou as test sets. A total of 35 clinical biochemical indexes were tested, including blood cells, immuno-inflammatory factors, liver enzymes, glycemic and lipid parameters, and thyroid and gonadal hormones. A stepwise analysis of a multivariable logistic regression was performed to build a predictive model to identify BD and MDD.

Results

Most of these biochemical indexes showed significant differences between BD and MDD groups, such as white blood cell (WBC) in t

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9251015 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature