N ⁶-Methyladenosine Methylomic Landscape of Ureteral Deficiency in Reflux Uropathy and Obstructive Uropathy.

ABSTRACT:

Background

Congenital anomalies of the kidneys and urinary tracts (CAKUT) represent the most prevalent cause for renal failure in children. The RNA epigenetic modification N ⁶-methyladenosine (m⁶A) methylation modulates gene expression and function post-transcriptionally, which has recently been revealed to be critical in organ development. However, it is uncertain whether m⁶A methylation plays a role in the pathogenesis of CAKUT. Thus, we aimed to explore the pattern of m⁶A methylation in CAKUT.

Methods

Using m⁶A-mRNA epitranscriptomic microarray, we investigated the m⁶A methylomic landscape in the ureter tissue of children with obstructive megaureter (M group) and primary vesicoureteral reflux (V grou

SUBMITTER: Shi H 

PROVIDER: S-EPMC9251069 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature