Associations Between Serum Soluble α-Klotho and the Prevalence of Specific Cardiovascular Disease.

ABSTRACT:

Objective

Accumulating experimental evidence has identified the beneficial effects of the anti-aging protein, serum soluble α-Klotho, on longevity, and the cardiovascular system. Although a previous study has revealed the predictive value of α-Klotho on total cardiovascular disease (CVD), the associations between α-Klotho and specific CVDs, including congestive heart failure (CHF), coronary heart disease (CHD), myocardial infarction (MI), and stroke, remains to be fully elucidated in humans.

Methods

For 8,615 adults in the 2007 to 2016 National Health and Nutrition Examination Survey, stratified multivariable logistic regression models, restricted cubic spline curves, and subgroup analyses were used to evaluate the associations between α-Klotho and the four specific CVDs.

SUBMITTER: Xu JP 

PROVIDER: S-EPMC9251131 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature