The Kappa Opioid Receptor: A Promising Therapeutic Target for Multiple Pathologies.

ABSTRACT: Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system, where they modulate a range of physiological processes depending on their location, including stress, mood, reward, pain, inflammation, and remyelination. However, clinical use of KOR agonists is limited by adverse effects such as dysphoria, aversion, and sedation. Within the drug-development field KOR agonists have been extensively investigated for the treatment of many centrally mediated nociceptive disorders including pruritis and pain. KOR agonists are potential alternatives to mu-opioid receptor (MOR) agonists for the treatment of pain due to their anti-nociceptive effects, lack of abuse potential, and reduced respiratory depressive effects, however, dysphoric side-effects have limited their wides

SUBMITTER: Dalefield ML 

PROVIDER: S-EPMC9251383 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature