Systematic Review and Meta-Analysis of Cardiovascular Medications in Neonatal Hypotension.

ABSTRACT:

Background

Comparative studies among the various cardiovascular medications used for the treatment of neonatal hypotension are lacking.

Methods

This systematic review and pairwise meta-analysis of the anti-hypotensive treatments in preterm and term infants was conducted to evaluate efficacy and impact on outcome. Electronic databases were searched up to February 2021 for relevant articles. As an extension of the current approach for study selection, a machine learning technique was used. Only randomized controlled trials (RCTs) of inotropes, pressors, volume therapy, and corticosteroids were included. Response to treatment was the primary outcome while secondary outcomes included mortality and common morbidities.

Results

Nineteen RCTs involving 758 preterm and term ne

SUBMITTER: Sarafidis K 

PROVIDER: S-EPMC9251481 | biostudies-literature | 2022 May-Aug

REPOSITORIES: biostudies-literature