Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation.

ABSTRACT:

Objective

Andrographis paniculata (Burm.f.) Nees is a medicinal plant that has been traditionally used as an anti-inflammatory and antibacterial remedy for several conditions. Andrographolide (AG), the active constituent of A. paniculata (Burm.f.) Nees, has anti-lipidic and anti-inflammatory properties as well as cardiovascular protective effects. The present study aimed to explore the effects of AG on the progression of atherosclerosis and to investigate related mechanisms via network pharmacology.

Materials and methods

Compound-related information was obtained from the PubChem database. Potential target genes were identified using STITCH, SwissTargetPrediction, Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine, and Comparative Toxicogenom

SUBMITTER: Shi S 

PROVIDER: S-EPMC9251584 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature