Molecular mechanisms of cystic fibrosis - how mutations lead to misfunction and guide therapy.

ABSTRACT: Cystic fibrosis, the most common autosomal recessive disorder in Caucasians, is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a cAMP-activated chloride and bicarbonate channel that regulates ion and water transport in secretory epithelia. Although all mutations lead to the lack or reduction in channel function, the mechanisms through which this occurs are diverse - ranging from lack of full-length mRNA, reduced mRNA levels, impaired folding and trafficking, targeting to degradation, decreased gating or conductance, and reduced protein levels to decreased half-life at the plasma membrane. Here, we review the different molecular mechanisms that cause cystic fibrosis and detail how these differences identify theratypes that can infor

SUBMITTER: Farinha CM 

PROVIDER: S-EPMC9251585 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature