Severity of alcohol use disorder influences sex differences in sleep, mood, and brain functional connectivity impairments.

ABSTRACT: Growing evidence suggests greater vulnerability of women than men to the adverse effects of alcohol on mood and sleep. However, the underlying neurobiological mechanisms are still poorly understood. Here, we examined sex difference in resting state functional connectivity in alcohol use disorder using a whole-brain data driven approach and tested for relationships with mood and self-reported sleep. To examine whether sex effects vary by severity of alcohol use disorder, we studied two cohorts: non-treatment seeking n = 141 participants with alcohol use disorder (low severity; 58 females) from the Human Connectome project and recently detoxified n = 102 treatment seeking participants with alcohol use disorder (high severity; 34 females) at the National Institute on Alcohol Abu

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9251604 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature